Main Street in St. Charles MO

Nestled right along the Missouri River, Main Street in St. Charles has long been the hub of commercial activity for St. Charles. The 13-block stretch of downtown St. Charles runs from Boone’s Lick Road to Clark, and boasts a bevy of shops, restaurants and businesses.

Come stroll the sidewalks that line real brick streets, have a glass of wine and shop a wide variety of stores for crafts and antiques.


  • Tonys on Main
  • RT Weiler’s
  • Quintessential Dining and NIghtlife
  • Trailhead Brewery
  • Lewis and Clark


  • Thro’s and Michelles
  • Figueros


  • Quintessential Nightclub
  • Lloyd and Harrys
  • Main Street Bistro
  • Red Room

Main Street in St. Charles